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J Autism Dev Disord. 2018 Sep 3. doi: 10.1007/s10803-018-3743-2. [Epub ahead of print]

Gastrointestinal Symptoms and Oral Antibiotic Use in Children with Autism Spectrum Disorder: Retrospective Analysis of a Privately Insured U.S. Population.

Author information

1
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, NY, 12180, USA.
2
OptumLabs Visiting Fellow, Rensselaer Polytechnic Institute, Troy, NY, USA.
3
Department of Computer Science, Rensselaer Polytechnic Institute, Troy, NY, USA.
4
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, NY, 12180, USA. hahnj@rpi.edu.
5
Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA. hahnj@rpi.edu.

Abstract

A retrospective analysis of administrative claims data from a large U.S. health insurer was performed to study a potential association between oral antibiotic use during early childhood and occurrence of later gastrointestinal (GI) symptoms in children with autism spectrum disorder (ASD). Among 3253 children with ASD, 37.0% had a GI-related diagnosis during the last 2 years of their 5-year health coverage enrollment period, compared to 20.0% of 278,370 children from the general population without an ASD diagnosis. Greater numbers of oral antibiotic fills during the first 3 years of enrollment were found to significantly increase the hazard rate of having a later GI-related diagnosis (adjusted hazard ratio 1.48; 95% confidence interval 1.34, 1.63) in children both with and without ASD.

KEYWORDS:

Administrative claims; Autism spectrum disorder; Gastrointestinal symptoms; Gut microbiome; Oral antibiotics; Retrospective analysis

PMID:
30178105
DOI:
10.1007/s10803-018-3743-2

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