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Chin J Integr Med. 2018 Dec;24(12):950-955. doi: 10.1007/s11655-018-2569-2. Epub 2018 Sep 4.

Research Progress of Angiogenesis in Atherosclerotic Plaque in Chinese Medicine and Western Medicine.

Author information

1
The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China.
2
The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China. maoweilw@163.com.

Abstract

Angiogenesis in atherosclerotic plaque plays a critical role in the mechanism of atherosclerotic physiopathology. Present consensus shows that angiogenesis in atherosclerotic plaque is mainly resulted in hypoxia, inflammation and some pro-angiogenic factors. The homeostasis in plaque, which is hypoxic and infiltrated by inflammatory cells, may lead to angiogenesis, increase the plaque instability and the incidence rate of vascular events. This article reviews the progression of pathogenetic mechanism, physiopathological significance, relevant detecting technique and corresponding therapeutic methods of Chinese and Western medicine of angiogenesis in atherosclerotic plaque, so as to provide more theoretical basis for atherosclerotic clinical treatment.

KEYWORDS:

Chinese medicine; Western medicine; angiogenesis; atherosclerotic plaque

PMID:
30178090
DOI:
10.1007/s11655-018-2569-2
[Indexed for MEDLINE]

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