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Encephale. 2018 Sep;44(4):379-386. doi: 10.1016/j.encep.2018.08.001. Epub 2018 Aug 31.

[Switching and stopping antidepressants].

[Article in French]

Author information

1
Service hospitalo-universitaire, centre hospitalier Sainte-Anne, 1, rue Cabanis, 75014 Paris, France. Electronic address: clairgauthier@gmail.com.
2
Service hospitalo-universitaire, centre hospitalier Sainte-Anne, 1, rue Cabanis, 75014 Paris, France.
3
Service hospitalo-universitaire, centre hospitalier Sainte-Anne, 1, rue Cabanis, 75014 Paris, France; Inserm UMR S894, université Paris Descartes, Sorbonne Paris Cité, 2, ter rue d'Alésia, 75014 Paris, France; Laboratoire de physiopathologie des maladies psychiatriques, Inserm UMR S894, centre de psychiatrie et neurosciences, 2, ter rue d'Alésia, 75014 Paris, France.

Abstract

Major depressive disorder (MDD) is a common, typically recurrent, sometimes chronic and very disabling disorder, with a lifetime prevalence of 20%. Moreover, antidepressant treatments may be partially effective. Studies have found that up to 60% of patients with MDD do not fully respond to the first antidepressant prescribed. Thus, switching antidepressants is a common strategy for antidepressant non-responders. When switching between antidepressants, an appropriate switching strategy should be used, depending on the characteristics of the first and the second antidepressant and patient's background. Patients should be informed that antidepressants can cause discontinuation symptoms if stopped abruptly after prolonged used. Relapse and exacerbation of depression can also occur during a switch. Thus, all antidepressant switches must be carried out cautiously and under close observation. This article summarizes the recommendations for an optimal antidepressant switch.

KEYWORDS:

Antidepressants; Antidépresseurs; Depression; Dépression; Switch

PMID:
30177305
DOI:
10.1016/j.encep.2018.08.001
[Indexed for MEDLINE]

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