Format

Send to

Choose Destination
Exp Mol Pathol. 2018 Dec;105(3):411-416. doi: 10.1016/j.yexmp.2018.08.012. Epub 2018 Aug 31.

Associations of tumor necrosis factor-α polymorphisms with the risk of asthma: a meta-analysis.

Author information

1
Department of Paediatrics, Taizhou People's Hospital, Taizhou, China.
2
Department of Orthopedics, Taizhou People's Hospital, Taizhou, China.
3
Department of Paediatrics, First Hospital of Jilin University, Changchun, China. Electronic address: hongmeiqiao99869@163.com.

Abstract

OBJECTIVE:

Recently, potential correlations between tumor necrosis factor-α (TNF-α) polymorphisms and asthma were investigated by some pilot studies, but the results of these studies were inconsistent. Therefore, we performed this meta-analysis to better evaluate the relationship between TNF-α polymorphisms and the risk of asthma.

METHODS:

Eligible studies were searched in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess correlations between TNF-α polymorphisms and asthma.

RESULTS:

A total of 50 studies were included for analyses. Significant associations with the risk of asthma were detected for TNF-α - 238 G/A, -308 G/A and - 857C/T polymorphisms in overall analyses. Further subgroup analyses according to ethnicity of participants revealed that TNF-α - 238 G/A polymorphism was significantly correlated with the risk of asthma in Caucasians, TNF-α - 308 G/A polymorphism was significantly correlated with the risk of asthma in West Asians, TNF-α - 857C/T polymorphism was significantly correlated with the risk of asthma in Caucasians, TNF-α - 863C/A polymorphism was significantly correlated with the risk of asthma in East Asians, and TNF-α - 1031 T/C polymorphism was significantly correlated with the risk of asthma in Caucasians and East Asians.

CONCLUSIONS:

Our findings indicated that TNF-α - 238 G/A, -308 G/A, -857C/T, -863C/A and - 1031 T/C polymorphisms may serve as potential biological markers for asthma in certain ethnicities.

KEYWORDS:

Asthma; Gene polymorphisms; Meta-analysis; Tumor necrosis factor-α (TNF-α)

PMID:
30176222
DOI:
10.1016/j.yexmp.2018.08.012
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center