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Rev Alerg Mex. 2018 Jul-Sep;65(3):142-152. doi: 10.29262/ram.v65i3.510.

[Omalizumab in children with uncontrolled asthma: a real-life study carried out in Colombia].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Hospital San Vicente Fundación, Departamento de Pediatría, Medellín, Colombia. lavusnino@gmail.com.

Abstract

in English, Spanish

BACKGROUND:

Omalizumab efficacy and safety in children older than 6 years has been clearly demonstrated in controlled clinical trials, but only in few real-life studies.

OBJECTIVE:

To assess the response with omalizumab addition in children with moderate to severe persistent asthma in real-life conditions.

METHODS:

Observational study with a 12-month real-life follow-up in a group of 61 children older than 6 years who were assessed for asthma control before treatment was started and at 4 and 12 months.

RESULTS:

After 12 months of treatment with omalizumab, there was symptom improvement both for those younger and older than 12 years (p = 0.001). There was a decrease in controller drug consumption in 73% of patients; in 61%, inhaled corticosteroid dose was reduced, and 8% discontinued its use. Inhaled corticosteroid average dose was decreased to 396 ± 298 µg, with this being statistically significant (p = 0.02).

CONCLUSION:

Omalizumab is an efficacious, safe and well-tolerated drug as add-on therapy for clinical control of moderate and severe allergic asthma that has not improved with standard therapies.

KEYWORDS:

Adolescent; Asthma; Child; Observational study; Omalizumab

PMID:
30176200
DOI:
10.29262/ram.v65i3.510

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