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J Orthop Res. 2018 Sep 3. doi: 10.1002/jor.24137. [Epub ahead of print]

Unravelling the hip pistol grip/cam deformity: Origins to joint degeneration.

Author information

1
The Ottawa Hospital, 501 Smyth Road, Ottawa, Ontario, K1H 8L6.
2
Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, K1S 5B6.
3
Human Movement Biomechanics Laboratory, University of Ottawa, 200 Lees Avenue, Ottawa, Ontario, K1N 6N5.
4
Department of Mechanical Engineering, Imperial College London, London, SW7 2AZ, UK.
5
The Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, K1H 8L1.

Abstract

This article reviews a body of work performed by the investigators over 9 years that has addressed the significance of cam morphology in the development of hip osteoarthritis (OA). Early hip joint degeneration is a common clinical presentation and preexisting abnormal joint morphology is a risk factor for its development. Interrogating Hill's criteria, we tested whether cam-type femoroacetabular impingement leads to hip OA. Strength of association was identified between cam morphology, reduced range-of-movement, hip pain, and cartilage degeneration. By studying a pediatric population, we were able to characterize the temporality between cam morphology (occurring 1st) and joint degeneration. Using in silico (finite element) and in vivo (imaging biomarkers) studies, we demonstrated the biological plausibility of how a cam deformity can lead to joint degeneration. Furthermore, we were able to show a biological gradient between degree of cam deformity and extent of articular damage. However, not all patients develop joint degeneration and we were able to characterize which factors contribute to this (specificity). Lastly, we were able to show that by removing the cam morphology, one could positively influence the degenerative process (experiment). The findings of this body of work show consistency and coherence with the literature. Furthermore, they illustrate how cam morphology can lead to early joint degeneration analogous to SCFE, dysplasia, and joint mal-reduction post-injury. The findings of this study open new avenues on the association between cam morphology and OA including recommendations for the study, screening, follow-up, and assessment (patient-specific) of individuals with cam morphology in order to prevent early joint degeneration. Statement of significance: By satisfying Hill's criteria, one can deduct that in some individuals, cam morphology is a cause of OA. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 9999:XX-XX, 2018.

KEYWORDS:

cam morphology; hip; impingement; osteoarthritis

PMID:
30175856
DOI:
10.1002/jor.24137

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