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Orv Hetil. 2018 Sep;159(36):1475-1482. doi: 10.1556/650.2018.31138.

[Intra-articular steroid and hyaluronic acid treatment of internal derangement of the temporomandibular joint].

[Article in Hungarian; Abstract available in Hungarian from the publisher]

Author information

Arc-, Állcsont-, Szájsebészeti és Fogászati Klinika, Semmelweis Egyetem, Fogorvostudományi Kar Budapest.
Fogpótlástani Klinika, Semmelweis Egyetem, Fogorvostudományi Kar Budapest.
Orális Diagnosztikai Tanszék, Semmelweis Egyetem, Fogorvostudományi Kar Budapest.


in English, Hungarian


Derangement of the temporomandibular joint complicates everyday life, due to the masticatory malfunction and the continuous pain sensation of the head and facial region. The therapy is multidisciplinary and varying. In case of the inefficiency of conservative therapy, minimally invasive intervention is needed with intraarticular injection.


The aim of our study was to examine whether hyaluronic acid injection is more beneficial compared to corticosteroid in 37 joints. We also examined whether the efficacy of the therapy is influenced by hyaluronic acid molecular weight and the used protocol.


Wilkes stage, maximal mouth opening and the Visual Analogue Scale were determined pre-operatively and 6 months later. Corticosteroid application was performed once, hyaluronic acid was injected on a weekly bases 3 times in a row, by use of low (6-10 × 105 dalton) or high molecular weight (24-36 × 105 dalton) preparations.


The medical state of the patients treated with corticosteroid temporarily improved, but the symptoms returned. Due to hyaluronic acid treatment, significant improvement was revealed in all parameters (pwilkes<0.0001; pmouth-opening = 0.0002; pVAS<0.0001). There was no significant relapse (T = 2.05). The third administration of hyaluronic acid resulted in a significant improvement of the Visual Analogue Scale compared to the first and second injection (T3.-1. = 20.37; T3.-2. = 9.57).


Comparing the two agents we can state that hyaluronic acid was significantly more effective and its application for three times seems to be the most effective treatment decreasing the symptoms. The high molecular weight solution was more effective in increasing mouth opening. In contrast to hyaluronic acid, corticosteroid had no prolonged effect in higher Wilkes stages. Orv Hetil. 2018; 159(36): 1475-1482.


corticosteroid; hialuronsav; hyaluronic acid; kortikoszteroid; molecular weight; molekulasúly; temporomandibular joint; temporomandibularis ízület

[Indexed for MEDLINE]

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