Format

Send to

Choose Destination
Metallomics. 2018 Oct 17;10(10):1452-1459. doi: 10.1039/c8mt00160j. Epub 2018 Sep 3.

Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru-papain conjugate.

Author information

1
Univ. Grenoble Alpes, CEA, CNRS, IBS, Metalloproteins, F-38000 Grenoble, France. juan.fontecilla@ibs.fr.
2
Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire (IPCM), 4 place Jussieu, 75005, Paris, France.

Abstract

The X-ray structure of an aerated achiral Ru-papain conjugate has revealed the hydroxylation of two tyrosine residues found near the ruthenium ion. The most likely mechanism involves a ruthenium-bound superoxide as the reactive species responsible for the first hydroxylation and the resulting high valent Ru(iv)[double bond, length as m-dash]O species for the second one.

PMID:
30175357
DOI:
10.1039/c8mt00160j
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Royal Society of Chemistry
Loading ...
Support Center