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Oxid Med Cell Longev. 2018 Aug 2;2018:1454936. doi: 10.1155/2018/1454936. eCollection 2018.

Antioxidants from Plants Protect against Skin Photoaging.

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Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte Sant'Angelo, via Cinthia 4, 80126 Naples, Italy.
Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden.
Department of Agricultural Sciences, University of Naples Federico II, via Università 100, 80055 Portici, Naples, Italy.
Istituto Nazionale di Biostrutture e Biosistemi (INBB), Rome, Italy.


Exposure to UV light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, with consequent increase in oxidative stress and thus in photoaging. Exogenous supplementation with dietary antioxidants and/or skin pretreatment with antioxidant-based lotions before sun exposure might be a winning strategy against age-related skin pathologies. In this context, plants produce many secondary metabolites to protect themselves from UV radiations and these compounds can also protect the skin from photoaging. Phenolic compounds, ascorbic acid and carotenoids, derived from different plant species, are able to protect the skin by preventing UV penetration, reducing inflammation and oxidative stress, and influencing several survival signalling pathways. In this review, we focus our attention on the double role of oxidants in cell metabolism and on environmental and xenobiotic agents involved in skin photoaging. Moreover, we discuss the protective role of dietary antioxidants from fruits and vegetables and report their antiaging properties related to the reduction of oxidative stress pathways.

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