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Front Behav Neurosci. 2018 Aug 17;12:169. doi: 10.3389/fnbeh.2018.00169. eCollection 2018.

Interictal Abnormalities of Neuromagnetic Gamma Oscillations in Migraine Following Negative Emotional Stimulation.

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Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Department of Medical Information and Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu, China.
Department of Neurology, School of Medicine, Nanjing University, Nanjing, China.
Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Sciences and Technology, University of Electronic Science and Technology of China, Chengdu, China.


Here, we aimed to investigate brain activity in migraineurs in response to emotional stimulation. Magnetoencephalography (MEG) was used to examine 20 patients with episodic migraine (EM group), 15 patients with chronic migraine (CM group), and 35 healthy participants (control group). Neuromagnetic brain activity was elicited by emotional stimulation using photographs of facial expressions. We analyzed the latency and amplitude of M100 and M170 components and used Morlet wavelet and beamformers to analyze the spectral and spatial signatures of MEG signals in gamma band (30-100 Hz). We found that the timing and frequency of MEG activity differed across the three groups in response negative emotional stimuli. First, peak M170 amplitude was significantly lower in the CM group than in the control group. Second, compared with the control group, the average spectral power was significantly lower in the EM group and CM group at M100 and M170. Third, the average spectral powers of the M100 and M170 in the CM group were negatively correlated with either HAM-D scores or migraine attack frequency. No significant differences across groups was found for positive or neutral emotional stimuli. Furthermore, after negative emotional stimuli, the MEG source analysis demonstrated that the CM group showed a significantly higher percentage of amygdala activation than the control group for M100 and M170. Thus, during headache free phases, migraineurs have abnormal brain activity in the gamma band in response to negative emotional stimuli. Trial Registration: ChiCTR-RNC-17012599. Registered 7 September, 2017.


M100; M170; emotional stimulation; gamma oscillation; magnetoencephalography; migraine

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