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Int J Hyg Environ Health. 2019 Jan;222(1):22-29. doi: 10.1016/j.ijheh.2018.07.015. Epub 2018 Aug 30.

Cancers in France in 2015 attributable to occupational exposures.

Author information

1
Section of Cancer Surveillance, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, CEDEX 08, France. Electronic address: marantmicallefc@iarc.fr.
2
Section of Cancer Surveillance, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, CEDEX 08, France. Electronic address: kevin.david.shield@gmail.com.
3
Section of Cancer Surveillance, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, CEDEX 08, France. Electronic address: vignatj@iarc.fr.
4
Equipe Santé Environnement, Centre de recherche INSERM U 897, Université de Bordeaux, Bât. ISPED - Case 11, 146, rue Léo-Saignat, Bordeaux, France. Electronic address: isabelle.baldi@u-bordeaux.fr.
5
Université Lyon 1, UMRESTTE, UMR_T9405, Service des maladies professionnelles, Hospices Civils de Lyon, 8, avenue Rockefeller, 69008, Lyon, France. Electronic address: barbara.charbotel-coing-boyat@univ-lyon1.fr.
6
Centre Léon Bérard, Université de Lyon, Département cancer environnement, 28 rue Laennec, 69008, Lyon, France. Electronic address: beatrice.fervers@lyon.unicancer.fr.
7
Santé publique France, Direction Santé Travail, 12, rue du Val d'Osne, 94 415, Saint-Maurice cedex, France. Electronic address: Anabelle.GILGSOITILG@santepubliquefrance.fr.
8
Centre de recherche en Epidémiologie et Santé des Populations (CESP), Cancer and Environment team, Université Paris-Sud, Université Paris-Saclay, 16, avenue Paul Vaillant Couturier, 94800, Villejuif, France. Electronic address: pascal.guenel@inserm.fr.
9
Section of Environment and Radiation, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, CEDEX 08, France. Electronic address: olssona@iarc.fr.
10
Department of Epidemiology and Biostatistics, Imperial College London, Level 2, Faculty Building, South Kensington Campus, London, SW7 2AZ, United Kingdom. Electronic address: l.rushton@imperial.ac.uk.
11
Manchester University, Population Health, Health Services Research & Primary Care, School of Health Sciences, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. Electronic address: sally.hutchings@postgrad.manchester.ac.uk.
12
Direction of Health and Environment, Institute for Radiological Protection and Nuclear Safety, 31, avenue de la Division Leclerc 92260, Fontenay-aux-Roses, 92260, France. Electronic address: enora.clero@irsn.fr.
13
Direction of Health and Environment, Institute for Radiological Protection and Nuclear Safety, 31, avenue de la Division Leclerc 92260, Fontenay-aux-Roses, 92260, France. Electronic address: dominique.laurier@irsn.fr.
14
Direction of Health and Environment, Institute for Radiological Protection and Nuclear Safety, 31, avenue de la Division Leclerc 92260, Fontenay-aux-Roses, 92260, France. Electronic address: pascale.scanff@irsn.fr.
15
Section of Cancer Surveillance, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, CEDEX 08, France. Electronic address: brayf@iarc.fr.
16
Section of Evidence Synthesis and Classification, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, CEDEX 08, France. Electronic address: straifk@iarc.fr.
17
Section of Cancer Surveillance, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, CEDEX 08, France. Electronic address: SoerjomataramI@iarc.fr.

Abstract

BACKGROUND:

Recent and comprehensive estimates for the number of new cancer cases in France attributable to occupational exposures are lacking.

OBJECTIVES:

To estimate the number of new cancer cases attributable to occupational exposures, using a newly developed methodology and the most recent data, for a comprehensive set of occupational carcinogens in France in 2015.

METHODS:

Surveys among employees, the national labor force data, a cohort of agricultural workers, national monitoring of workers exposed to ionizing radiation and job-exposure matrix in France were used. The number and proportion of new cancer cases attributable to established occupational carcinogens (Group 1) was estimated using estimation of lifetime exposure and risk estimates from cohort studies. Cancer data were obtained from the French Cancer Registries Network.

RESULTS:

In France in 2015, an estimated 7905 new cancer cases, 7336 among men and 569 among women, were attributable to occupational exposures, representing 2.3% of all new cancer cases (3.9% and 0.4% among men and women respectively). Among men and women, lung cancer was impacted the most, followed by mesothelioma and bladder cancer in men, and by mesothelioma and ovary in women. These cancers contributed to 89% of the total cancers attributable to occupational carcinogens in men, and to 80% in women. The main contributing occupational agent was asbestos among men (45%) and women (60%).

CONCLUSIONS:

Currently, occupational exposures contribute to a substantial burden of cancer in France. Enhanced monitoring and implementation of protective labor policies could potentially prevent a large proportion of these cancers.

KEYWORDS:

Cancer; Carcinogen; Comparative risk assessment/attributable fractions; Occupation; Risk

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