Potential Prognostic, Diagnostic and Therapeutic Markers for In-stent Reocclusion in Advanced Age Patients After Coronary Stenting

Curr Pharm Des. 2018;24(28):3359-3365. doi: 10.2174/1381612824666180830141918.

Abstract

Background: Oxidative stress and inflammatory response played important roles in advanced atherosclerosis. We tried to confirm clinical diagnostic significance of the assessments of oxidative stress and inflammatory response status with in-stent reocclusion in 283 advanced age patients (80~90 years) after coronary stenting.

Methods: We analyzed levels of circulating superoxide dismutase 3 (SOD3), nitric oxide (NO), endothelial nitric oxide synthase (eNOS), malondialdehyde (MDA), acrolein(ACR), and paraoxonase-1 (PON-1)in advanced age patients with in-stent restenosis and reocclusion after coronary stenting.

Results: Levels of SOD3, eNOS, NO and PON-1 were lowered (P<0.001) and levels of MDA and ACR were increased (P<0.001).

Conclusion: The assessments of the biomarkers of oxidative stress and inflammatory response (levels of MDA and ACR) and anti-oxidant biomarkers (levels of eNOS, NO, SOD3 and PON-1) could be considered as potential prognostic and diagnostic indicators of in-stent reocclusion in advanced age patients after coronary stenting.

Keywords: Coronary heart disease; atherosclerosis; coronary artery; coronary stenting; in-stent reocclusion; oxidative stress..

MeSH terms

  • Aged, 80 and over
  • Biomarkers / analysis
  • Biomarkers / metabolism
  • Coronary Angiography*
  • Female
  • Humans
  • Inflammation* / diagnosis
  • Inflammation* / surgery
  • Inflammation* / therapy
  • Male
  • Oxidative Stress
  • Prognosis
  • Stents*

Substances

  • Biomarkers