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Connect Tissue Res. 2018 Sep 20:1-8. doi: 10.1080/03008207.2018.1517759. [Epub ahead of print]

Arthrofibrosis and large joint scarring.

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a Department of Orthopaedic Surgery , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
b Department of Orthopedic Surgery , Seoul National University College of Medicine, Seoul National University Bundang Hospital , Seoul , Korea.
c Division of Sports Medicine and Shoulder Surgery, Department of Orthopaedics , University of Colorado , Aurora , CO , USA.
d Department of Orthopaedics , Rothman Institute at Thomas Jefferson University , Philadelphia , PA , USA.


Large joint arthrofibrosis and scarring, involving the shoulder, elbow, hip, and knee, can result in the loss of function and immobility. The pathway of joint contracture formation is still being elucidated and is due to aberrations in collagen synthesis and misorientation of collagen fibrils. Novel antibodies are being developed to prevent arthrofibrosis, and current treatment methods for arthrofibrosis include medical, physical, and surgical treatments. This article describes the biology of joint contracture formation, along with current and future pharmacologic, biologic, and medical interventions.


Antibody; arthrofibrosis; collagen synthesis; knee; large joint; scar; shoulder

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