Format

Send to

Choose Destination
BMJ Case Rep. 2018 Sep 1;2018. pii: bcr-2018-225871. doi: 10.1136/bcr-2018-225871.

Infective endocarditis due to Atopobium vaginae: a rare association between genital infection and endocarditis of the tricuspid valve.

Author information

1
Department of Cardiology, Barts Health NHS Trust, London, UK.
2
Department of Microbiology, North Middlesex University Hospital NHS Trust, London, UK.
3
Department of Virology, Royal Free Hospital, London, UK.
4
Division of Infection, Barts Health NHS Trust, London, UK.

Abstract

Atopobium vaginae is an anaerobic gram-positive organism associated with genitourinary infections. Bacteraemia is rare, with only two cases reported in the literature. This case describes an 18-year-old type 1 diabetic, presenting with sepsis and haemoptysis, on a background of poor dental hygiene and recurrent hospital admissions. Blood cultures grew A. vaginae and echocardiogram revealed a large tricuspid valve lesion. Despite medical therapy, symptoms of pulmonary emboli continued and she therefore underwent surgical resection of the lesion. Histopathological findings were of a vegetation; culture of the lesion was negative but 16S ribosomal PCR was positive, detecting 16S rRNA of A. vaginae The patient was treated with 4 weeks of vancomycin and made a good recovery. To our knowledge, this represents the first report of infective endocarditis due to this organism. We also provide a review of the literature, including comparing published drug susceptibility data with consensus breakpoints for antimicrobial agents.

KEYWORDS:

cardiothoracic surgery; infections; radiology (diagnostics); valvular disease

PMID:
30173134
DOI:
10.1136/bcr-2018-225871
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center