Send to

Choose Destination
BMJ Case Rep. 2018 Sep 1;2018. pii: bcr-2018-225871. doi: 10.1136/bcr-2018-225871.

Infective endocarditis due to Atopobium vaginae: a rare association between genital infection and endocarditis of the tricuspid valve.

Author information

Department of Cardiology, Barts Health NHS Trust, London, UK.
Department of Microbiology, North Middlesex University Hospital NHS Trust, London, UK.
Department of Virology, Royal Free Hospital, London, UK.
Division of Infection, Barts Health NHS Trust, London, UK.


Atopobium vaginae is an anaerobic gram-positive organism associated with genitourinary infections. Bacteraemia is rare, with only two cases reported in the literature. This case describes an 18-year-old type 1 diabetic, presenting with sepsis and haemoptysis, on a background of poor dental hygiene and recurrent hospital admissions. Blood cultures grew A. vaginae and echocardiogram revealed a large tricuspid valve lesion. Despite medical therapy, symptoms of pulmonary emboli continued and she therefore underwent surgical resection of the lesion. Histopathological findings were of a vegetation; culture of the lesion was negative but 16S ribosomal PCR was positive, detecting 16S rRNA of A. vaginae The patient was treated with 4 weeks of vancomycin and made a good recovery. To our knowledge, this represents the first report of infective endocarditis due to this organism. We also provide a review of the literature, including comparing published drug susceptibility data with consensus breakpoints for antimicrobial agents.


cardiothoracic surgery; infections; radiology (diagnostics); valvular disease

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center