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Clin Nutr. 2018 Aug 16. pii: S0261-5614(18)31349-9. doi: 10.1016/j.clnu.2018.08.007. [Epub ahead of print]

Fish intake and risk of mortality due to aortic dissection and aneurysm: A pooled analysis of the Japan cohort consortium.

Author information

1
Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. Electronic address: yamagishi.kazumas.ge@u.tsukuba.ac.jp.
2
Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
3
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
4
Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
5
Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan; Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
6
Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
7
Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
8
Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.
9
Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
10
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
11
Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
12
Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
13
Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan.
14
Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.

Abstract

BACKGROUND & AIMS:

Many studies have suggested that fish intake is associated with protection from risk of atherosclerotic diseases; however, this association with aortic diseases has not been elucidated worldwide. We hypothesized that fish intake is inversely associated with mortality from aortic diseases (aortic dissection and aneurysm).

METHODS:

The study was conducted as a pooled analysis of original data from a maximum of 8 cohort studies, comprising a total of 366,048 community-based men and women who had no history of cardiovascular disease or cancer. In each cohort, we used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality from aortic dissection, aneurysm and total aortic disease according to the frequency of fish intake and estimated summary HRs derived from each study.

RESULTS:

Nonlinear inverse associations were found between fish intake and total aortic disease. Compared with persons who ate fish 1-2 times/week, persons who seldom ate fish had higher mortality from total aortic disease (multivariable-adjusted pooled HR = 1.93; 95% CI, 1.13-3.31). Higher mortality was not seen in those who ate fish 1-2 times/month. A similar pattern was observed for aortic dissection. Regarding aortic aneurysm, both persons who seldom ate fish and those who ate fish 1-2 times/month had higher mortality (HR = 1.99; 95% CI, 0.90-4.40 and HR = 1.86; 95% CI, 0.87-3.98, respectively).

CONCLUSIONS:

Persons who seldom ate fish had higher mortality from aortic dissection, aneurysm, and total aortic diseases.

KEYWORDS:

Diet; Epidemiology; Fatty acids; Meta-analysis; Prospective cohort study

PMID:
30172657
DOI:
10.1016/j.clnu.2018.08.007

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