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Environ Int. 2018 Nov;120:544-562. doi: 10.1016/j.envint.2018.07.037. Epub 2018 Aug 28.

Current EU research activities on combined exposure to multiple chemicals.

Author information

1
European Commission, Directorate General Joint Research Centre, Directorate F - Health, Consumers and Reference Materials, Ispra, Italy. Electronic address: stephanie.bopp@ec.europa.eu.
2
INSERM UMR-S 1124, Université Paris Descartes, Paris, France. Electronic address: robert.barouki@parisdescartes.fr.
3
Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany. Electronic address: werner.brack@ufz.de.
4
European Commission, Directorate General Joint Research Centre, Directorate B - Growth and Innovation, Ispra, Italy. Electronic address: silvia.dalla-costa@ec.europa.eu.
5
Scientific Committee and Emerging Risks Unit, European Food Safety Authority (EFSA), Parma, Italy. Electronic address: jean-lou.dorne@efsa.europa.eu.
6
Swetox, Karolinska Institutet, Unit of Toxicology Sciences, Södertälje, Sweden. Electronic address: elina.drakvik@swetox.se.
7
Faust & Backhaus Environmental Consulting, Bremen, Germany. Electronic address: faust@fb-envico.com.
8
European Commission, Directorate General Research and Innovation, Directorate E - Health, Brussels, Belgium. Electronic address: tuomo.karjalainen@ec.europa.eu.
9
European Commission, Directorate General Joint Research Centre, Directorate F - Health, Consumers and Reference Materials, Ispra, Italy. Electronic address: stylianos.kephalopoulos@ec.europa.eu.
10
National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Electronic address: jacob.van.klaveren@rivm.nl.
11
German Environment Agency, UBA, Berlin, Germany. Electronic address: marike.kolossa@uba.de.
12
Institute for Environment, Health and Societies, Brunel University, Uxbridge, United Kingdom. Electronic address: andreas.kortenkamp@brunel.ac.uk.
13
National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Institute of Risk Assessment Sciences - IRAS, Utrecht University, Utrecht, the Netherlands. Electronic address: erik.lebret@rivm.nl.
14
European Commission, Directorate General Joint Research Centre, Directorate D - Sustainable Resources, Ispra, Italy. Electronic address: teresa.lettieri@ec.europa.eu.
15
European Commission, Directorate General Research and Innovation, Directorate E - Health, Brussels, Belgium. Electronic address: sofie.norager@ec.europa.eu.
16
Swetox, Karolinska Institutet, Unit of Toxicology Sciences, Södertälje, Sweden. Electronic address: joelle.ruegg@swetox.se.
17
Pesticides Unit, European Food Safety Authority (EFSA), Parma, Italy. Electronic address: jose.tarazona@efsa.europa.eu.
18
European Environment Agency, Copenhagen, Denmark. Electronic address: xenia.trier@eea.europa.eu.
19
Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. Electronic address: b.water@lacdr.leidenuniv.nl.
20
Deltares, Delft, the Netherlands. Electronic address: jos.vangils@deltares.nl.
21
Swetox, Karolinska Institutet, Unit of Toxicology Sciences, Södertälje, Sweden; School of Science and Technology, MTM, Örebro University, Örebro, Sweden. Electronic address: ake.bergman@swetox.se.

Abstract

Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purposes mainly relies on the assessment of individual chemicals. If exposure to multiple chemicals is considered in a legislative framework, it is usually limited to chemicals falling within this framework and co-exposure to chemicals that are covered by a different regulatory framework is often neglected. Methodologies and guidance for assessing risks from combined exposure to multiple chemicals have been developed for different regulatory sectors, however, a harmonised, consistent approach for performing mixture risk assessments and management across different regulatory sectors is lacking. At the time of this publication, several EU research projects are running, funded by the current European Research and Innovation Programme Horizon 2020 or the Seventh Framework Programme. They aim at addressing knowledge gaps and developing methodologies to better assess chemical mixtures, by generating and making available internal and external exposure data, developing models for exposure assessment, developing tools for in silico and in vitro effect assessment to be applied in a tiered framework and for grouping of chemicals, as well as developing joint epidemiological-toxicological approaches for mixture risk assessment and for prioritising mixtures of concern. The projects EDC-MixRisk, EuroMix, EUToxRisk, HBM4EU and SOLUTIONS have started an exchange between the consortia, European Commission Services and EU Agencies, in order to identify where new methodologies have become available and where remaining gaps need to be further addressed. This paper maps how the different projects contribute to the data needs and assessment methodologies and identifies remaining challenges to be further addressed for the assessment of chemical mixtures.

PMID:
30170309
PMCID:
PMC6192826
DOI:
10.1016/j.envint.2018.07.037
[Indexed for MEDLINE]
Free PMC Article

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