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Eur J Neurol. 2019 Feb;26(2):238-245. doi: 10.1111/ene.13796. Epub 2018 Sep 24.

Restless legs syndrome is associated with headache-related disabilities in patients with migraine: a prospective 7-year follow-up study.

Author information

1
Department of Neurology, Dokkyo Medical University, Tochigi, Japan.
2
Department of Public Health School of Medicine, Dokkyo Medical University, Tochigi, Japan.

Abstract

BACKGROUND AND PURPOSE:

No prospective study has evaluated the impact of restless legs syndrome (RLS) on clinical factors in patients with migraine. We planned a prospective study to assess the impact of RLS comorbid status on clinical factors in patients with migraine.

METHODS:

A total of 101 patients with migraine who were evaluated for RLS twice at 7-year intervals in a university hospital setting were included in this study. The RLS group was defined as positive for RLS at either baseline or follow-up and the non-RLS group was defined as negative for RLS at both baseline and follow-up. The Migraine Disability Assessment (MIDAS) questionnaire, Beck Depression Inventory-II (BDI-II), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale were administered to all patients.

RESULTS:

The RLS prevalence was 16.8% at baseline and 20.8% at follow-up. Compared with the non-RLS group (n = 27), the RLS group (n = 74) showed a significantly higher rate of smoking and higher MIDAS and BDI-II scores at 7-year follow-up. A significant reduction in MIDAS and BDI-II scores at 7-year follow-up compared with those at baseline was observed in the non-RLS group, but not in the RLS group. The non-RLS group showed a significantly lower MIDAS score at 7-year follow-up than the RLS group after adjusting for confounding variables such as age, gender, smoking status, Epworth Sleepiness Scale and PSQI scores using analysis of covariance. The persistent RLS group (n = 11) (positive for RLS at both baseline and follow-up) showed a significantly higher rate of smoking and increased MIDAS, BDI-II and PSQI scores compared with the non-RLS group (n = 74) at 7-year follow-up.

CONCLUSION:

Our prospective study showed that RLS had a significant impact on headache-related disability in patients with migraine.

KEYWORDS:

headache-related disability; migraine; restless legs syndrome

PMID:
30169898
DOI:
10.1111/ene.13796

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