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Angiogenesis. 2019 Feb;22(1):15-36. doi: 10.1007/s10456-018-9645-2. Epub 2018 Aug 24.

Angiogenesis in pancreatic cancer: current research status and clinical implications.

Li S1,2,3,4, Xu HX1,2,3,4, Wu CT1,2,3,4, Wang WQ1,2,3,4, Jin W1,2,3,4, Gao HL1,2,3,4, Li H1,2,3,4, Zhang SR1,2,3,4, Xu JZ1,2,3,4, Qi ZH1,2,3,4, Ni QX1,2,3,4, Yu XJ5,6,7,8, Liu L9,10,11,12.

Author information

1
Department of Pancreatic & Hepatobiliary Surgery, Fudan University Shanghai Cancer Center, No. 270 Dong An Road, Shanghai, 200032, China.
2
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
3
Shanghai Pancreatic Cancer Institute, Shanghai, 200032, China.
4
Pancreatic Cancer Institute, Fudan University, Shanghai, 200032, China.
5
Department of Pancreatic & Hepatobiliary Surgery, Fudan University Shanghai Cancer Center, No. 270 Dong An Road, Shanghai, 200032, China. yuxianjun@fudanpci.org.
6
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. yuxianjun@fudanpci.org.
7
Shanghai Pancreatic Cancer Institute, Shanghai, 200032, China. yuxianjun@fudanpci.org.
8
Pancreatic Cancer Institute, Fudan University, Shanghai, 200032, China. yuxianjun@fudanpci.org.
9
Department of Pancreatic & Hepatobiliary Surgery, Fudan University Shanghai Cancer Center, No. 270 Dong An Road, Shanghai, 200032, China. liuliang@fudanpci.org.
10
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. liuliang@fudanpci.org.
11
Shanghai Pancreatic Cancer Institute, Shanghai, 200032, China. liuliang@fudanpci.org.
12
Pancreatic Cancer Institute, Fudan University, Shanghai, 200032, China. liuliang@fudanpci.org.

Abstract

Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year survival rate of <‚ÄČ5%. Angiogenesis, namely, the formation of new blood vessels from pre-existing vessels, is an important event in tumor growth and hematogenous metastasis. It is a dynamic and complex process involving multiple mechanisms and is regulated by various molecules. Inhibition of angiogenesis has been an established therapeutic strategy for many solid tumors. However, clinical outcomes are far from satisfying for pancreatic cancer patients receiving anti-angiogenic therapies. In this review, we summarize the current status of angiogenesis in pancreatic cancer research and explore the reasons for the poor efficacy of anti-angiogenic therapies, aiming to identify some potential therapeutic targets that may enhance the effectiveness of anti-angiogenic treatments.

KEYWORDS:

Angiogenesis; Anti-angiogenic therapy; Microvessel density; Pancreatic cancer; Stromal components

PMID:
30168025
DOI:
10.1007/s10456-018-9645-2

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