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Acta Diabetol. 2019 Jan;56(1):67-71. doi: 10.1007/s00592-018-1210-3. Epub 2018 Aug 28.

Impact of ranibizumab on visual impairment in patients with bilateral diabetic macular edema.

Author information

1
Ophthalmology, Centre d'Imagerie et de Laser, Paris, France.
2
Ophthalmology Department, Avicenne Hospital, Bobigny, France.
3
Partner California Retina Consultants, Director California Retina Research Foundation, Santa Barbara, USA.
4
Centre Hospitalier Intercommunal Créteil, Créteil, France.
5
Ophthalmology Department, Pitié Salpétrière Hospital, Paris, France.
6
Ophthalmology Department, Avicenne Hospital, Bobigny, France. Audrey.giocanti@aphp.fr.

Abstract

AIMS:

Diabetic macular edema (DME) frequently presents bilaterally. In case of bilateral retinal disease, the visual impairment (VI) and the visual acuity (VA) are strongly correlated to the better eye. The aim of this study was to assess the impact of ranibizumab intravitreal injections (IVR) on VI in patients with simultaneous VA loss due to DME.

METHODS:

This was a retrospective two-center study including consecutive DME patients with visual loss treated with ranibizumab since November 2011 and with a minimum follow-up of 6 months. Patients with bilateral visual decrease from DME undergoing IVR within 6 months of each other were included.

RESULTS:

Twenty-nine DME patients who received bilateral IVR within a 6-month interval in the second eye were included. At baseline, 82.8% (n = 24) of patients had a VA < 20/40 in their better eye versus 44.8% (n = 13) of patients at the end of follow-up, i.e. a reduction by 45.9% of VI. In the better eye, the mean VA was 57.3, 65.0 and 65.5 ETDRS letters, respectively, at baseline, month 3 and month 6 (mean VA gain +8.2 letters). In the worse eye, the mean VA was 44.2, 53.5 and 53.8 ETDRS letters, respectively, at baseline, M3 and M6 (mean VA gain +9.6 letters).

CONCLUSIONS:

In patients with bilateral DME, subsequent ranibizumab IVR reduced VI frequency.

KEYWORDS:

Anti-VEGF; Bilateral diabetic macular edema; Disability; Visual impairment

PMID:
30167869
DOI:
10.1007/s00592-018-1210-3
[Indexed for MEDLINE]

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