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PLoS One. 2018 Aug 30;13(8):e0202670. doi: 10.1371/journal.pone.0202670. eCollection 2018.

Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury.

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Laboratory of Probiogenomics, Department of Chemical Sciences, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
Food and Drug Department, University of Parma, Parma, Italy.
GenProbio srl, Parma, Italy.
Department of Veterinary Sciences, University of Parma, Parma, Italy.
APC Microbiome Institute and School of Microbiology, Bioscience Institute, National University of Ireland, Cork, Ireland.
Microbiome Research Hub, University of Parma, Parma, Italy.


Mesenteric ischemia/reperfusion is a clinical emergency with high morbidity and mortality due to the transient reduction of blood supply to the bowel. In recent years, the critical contribution of gut microbiome to human health and proper gastrointestinal functions has gradually emerged. In the current study, we investigated the protective effects of five days supplementation with Bifidobacterium bifidum PRL2010 in a murine model of gut ischemia/reperfusion. Our findings indicate that animals pretreated with B. bifidum PRL2010 showed lower neutrophil recruitment in the lungs, remarkably reduced bacterial translocation and decreased transcription levels of TNFalpha and IL-10 both in liver and kidneys, at the same time increasing those of IL-12 in kidneys. Inhibiting the adhesion of pathogenic bacteria and boosting host innate immunity responses are among the possible protective mechanisms enacted by the probiotic. These results demonstrate that short-period treatment with B. bifidum PRL2010 is a potential strategy to dampen remote organ injury due to mesenteric ischemia/reperfusion.

Conflict of interest statement

The authors have declared that no competing interests exist. L.M., M.M. and A.V. are employed by GenProbio s.r.l. but this commercial affiliation does not alter the adherence of the authors to PLOS ONE policies on sharing data and/or materials.

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