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Community Dent Oral Epidemiol. 2018 Dec;46(6):615-623. doi: 10.1111/cdoe.12414. Epub 2018 Aug 30.

Periodontitis and multiple markers of cardiometabolic risk in the fourth decade: A cohort study.

Author information

1
Department of Oral Sciences, Faculty of Dentistry, Dunedin, New Zealand.
2
Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
3
Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
4
Department of Ophthalmology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
5
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
6
Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
7
Duke-NUS Medical School, Singapore, Singapore.
8
Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

Abstract

OBJECTIVES:

To examine associations between periodontitis at ages 32 and 38 and a range of early cardiometabolic risk biomarkers at age 38.

METHODS:

Periodontal probing depth and bleeding on probing data collected during the age-32 and age-38 assessments in the Dunedin Multidisciplinary Health and Development Study were used to quantify periodontal inflammatory load. Retinal microvascular abnormalities, endothelial dysfunction, and metabolic syndrome data were collected during the age-38 assessment. Regression models were used to examine associations between these cardiometabolic risk markers and (1) the inflammatory load at age 38 and (2) the change in inflammatory load between ages 32 and 38.

RESULTS:

Periodontal inflammatory load was recorded for 890 Study members at age 32, 891 at age 38, and 856 at both ages. Retinal vessel data were available for 922, endothelial dysfunction data for 909 and metabolic syndrome data for 905 at age 38. Neither the inflammatory load of periodontitis at 38 nor the changes in inflammatory load 32-38 were found to be associated with any of the three cardiometabolic risk markers.

CONCLUSIONS:

Periodontitis was not associated with markers of cardiometabolic risk at this relatively early stage in the life course. It is possible that any influence of periodontitis on cardiometabolic health develops later in life, or periodontitis is not involved in the putative causal chain comprising systemic inflammation, cardiometabolic risk markers, and subsequent cardiovascular risk.

KEYWORDS:

cardiometabolic; endothelial dysfunction; metabolic syndrome; microcirculation; periodontitis; peripheral arterial tonometry; retinal vascular calibre

PMID:
30160305
PMCID:
PMC6237628
[Available on 2019-12-01]
DOI:
10.1111/cdoe.12414

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