Format

Send to

Choose Destination
Eur Radiol. 2018 Aug 29. doi: 10.1007/s00330-018-5679-5. [Epub ahead of print]

Hepatocellular carcinoma: CT texture analysis as a predictor of survival after surgical resection.

Author information

1
Service d'Hépato-Gastroentérologie et de Cancérologie Digestive, Centre Hospitalier Universitaire de Reims, 51092, Reims, France.
2
Service d'Imagerie Médicale, Centre Hospitalier Universitaire de Reims, Reims, France.
3
Laboratoire des Signaux et Systèmes, CentraleSupélec, Université Paris-Saclay, Gif sur Yvette, France.
4
Service de Chirurgie Générale, Digestive et Endocrine, Centre Hospitalier Universitaire de Reims, Reims, France.
5
CReSTIC, Université de Reims Champagne-Ardenne, Reims, France.
6
Service d'Hépato-Gastroentérologie et de Cancérologie Digestive, Centre Hospitalier Universitaire de Reims, 51092, Reims, France. gthiefin@chu-reims.fr.

Abstract

OBJECTIVES:

To determine whether image texture parameters analysed on pre-operative contrast-enhanced computed tomography (CT) can predict overall survival and recurrence-free survival in patients with hepatocellular carcinoma (HCC) treated by surgical resection.

METHODS:

We retrospectively included all patients operated for HCC who had liver contrast-enhanced CT within 3 months prior to treatment in our centre between 2010 and 2015. The following texture parameters were evaluated on late-arterial and portal-venous phases: mean grey-level, standard deviation, kurtosis, skewness and entropy. Measurements were made before and after spatial filtration at different anatomical scales (SSF) ranging from 2 (fine texture) to 6 (coarse texture). Lasso penalised Cox regression analyses were performed to identify independent predictors of overall survival and recurrence-free survival.

RESULTS:

Forty-seven patients were included. Median follow-up time was 345 days (interquartile range [IQR], 176-569). Nineteen patients had a recurrence at a median time of 190 days (IQR, 141-274) and 13 died at a median time of 274 days (IQR, 96-411). At arterial CT phase, kurtosis at SSF = 4 (hazard ratio [95% confidence interval] = 3.23 [1.35-7.71] p = 0.0084) was independent predictor of overall survival. At portal-venous phase, skewness without filtration (HR [CI 95%] = 353.44 [1.31-95102.23], p = 0.039), at SSF2 scale (HR [CI 95%] = 438.73 [2.44-78968.25], p = 0.022) and SSF3 (HR [CI 95%] = 14.43 [1.38-150.51], p = 0.026) were independently associated with overall survival. No textural feature was identified as predictor of recurrence-free survival.

CONCLUSIONS:

In patients with resectable HCC, portal venous phase-derived CT skewness is significantly associated with overall survival and may potentially become a useful tool to select the best candidates for resection.

KEY POINTS:

• HCC heterogeneity as evaluated by texture analysis of contrast-enhanced CT images may predict overall survival in patients treated by surgical resection. • Among texture parameters, skewness assessed at different anatomical scales at portal-venous phase CT is an independent predictor of overall survival after resection. • In patients with HCC, CT texture analysis may have the potential to become a useful tool to select the best candidates for resection.

KEYWORDS:

Computed tomography; Computer-assisted image analysis; Liver; Neoplasm; Survival

PMID:
30159621
DOI:
10.1007/s00330-018-5679-5

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center