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Chem Commun (Camb). 2018 Sep 13;54(74):10487-10490. doi: 10.1039/c8cc04898c.

Synthesis of highly controlled carbohydrate-polymer based hybrid structures by combining heparin fragments and sialic acid derivatives, and solid phase polymer synthesis.

Author information

1
Institute of Organic and Macromolecular Chemistry, Heinrich-Heine-University Duesseldorf, Universitaetsstrasse 1, Duesseldorf 40225, Germany. laura.hartmann@hhu.de.

Abstract

Heparin is a polymeric carbohydrate with a variety of biomedical applications that is particularly challenging from a synthetic point of view. Here, we present the synthesis of carbohydrate-polymer based hybrid structures by combining defined heparin fragments with monodisperse, sequence-controlled glycooligo(amidoamines) suitable as glycan mimetic model compounds of heparin as demonstrated by STD-NMR binding studies with viral capsids.

PMID:
30159562
DOI:
10.1039/c8cc04898c

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