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Bioinorg Chem Appl. 2018 Aug 12;2018:8547364. doi: 10.1155/2018/8547364. eCollection 2018.

An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules.

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Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, Canada H3A 3K6.


Carbon monoxide (CO) has long been known as the "silent killer" owing to its ability to form carboxyhemoglobin-the main cause of CO poisoning in humans. Its role as an endogenous neurotransmitter, however, was suggested in the early 1990s. Since then, the biological activity of CO has been widely examined via both the direct administration of CO and in the form of so-called "carbon monoxide releasing molecules (CORMs)." This overview will explore the general physiological effects and potential therapeutic applications of CO when delivered in the form of CORMs.

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