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J Oral Maxillofac Pathol. 2018 May-Aug;22(2):263-265. doi: 10.4103/jomfp.JOMFP_254_17.

Sclerosing polycystic adenosis of lower lip: A new and rare salivary gland entity.

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Department of Oral and Maxillofacial Pathology, P.M.N.M Dental College and Hospital, Bagalkot, Karnataka, India.


Sclerosing polycystic adenosis (SPA) was first described in 1996 by Smith et al. and was characterized by resemblance to epithelial proliferative lesions of the breast such as fibrocystic disease and sclerosing adenosis. Etiopathogenetically, it is generally believed to represent a nonneoplastic sclerosing and inflammatory process. The age range is broad (typically fourth decade), with a slight female predilection. The vast majority are parotid lesions, with very few in minor salivary glands. As of 2017, not more than 60 cases have been reported worldwide. Microscopically, it is characterized by a well-circumscribed to partially circumscribed tubulocystic proliferation of a gland within a sclerotic-fibrous stroma. Ductal epithelium showing variations such as foamy, mucous and apocrine are seen. We report a case of SPA of lower lip in a 70-year-old male.


Lip; minor salivary gland; sclerosing polycystic adenosis

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