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J Oral Maxillofac Pathol. 2018 May-Aug;22(2):260-262. doi: 10.4103/jomfp.JOMFP_161_17.

Aggressive histologic features do not predict biologic behavior in melanotic neuroectodermal tumor of infancy.

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Department of Surgical and Hospital Dentistry, University of Louisville School of Dentistry, Louisville, Kentucky, USA.


While generally benign, occasional aggressive histologic features in the melanotic neuroectodermal tumor of infancy (MNTI) have been used to justify a diagnosis of malignancy; this could lead to overtreatment. We report a case with presumed aggressive histologic features that did not recur following conservative treatment. This adds evidence that histologic features are not predictive of clinical behavior in MNTI.


CD99; Ki-67; malignant; melanotic neuroectodermal tumor; necrosis

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