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J Oral Maxillofac Pathol. 2018 May-Aug;22(2):239-244. doi: 10.4103/jomfp.JOMFP_113_16.

Host defense peptides: An insight into the antimicrobial world.

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Department of Periodontology, Subharti Dental College, Meerut, India.
Department of Periodontology, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India.


A serious challenge to antimicrobial therapies has emerged due to rapid increase in drug-resistant infections creating an urge for the development of alternative therapeutics. Antimicrobial peptides (AMPs) have gained importance because of their broad-spectrum antimicrobial activities and mediator-like functions linking innate and adaptive immune responses. The multidimensional properties of these peptides hold promising potentials as prophylactic and antimicrobial agents. This review discusses various AMPs and their role in combating microorganisms and infections along with its clinical implication.


Antimicrobial; inflammation and innate immunity; periodontitis

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