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J Antibiot (Tokyo). 2018 Nov;71(12):1018-1024. doi: 10.1038/s41429-018-0096-1. Epub 2018 Aug 29.

Cytotoxic antibiotic angucyclines and actinomycins from the Streptomyces sp. XZHG99T.

Author information

1
School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan, 250022, China.
2
School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan, 250022, China. bio_zhangh@ujn.edu.cn.

Abstract

Three new angucycline-type C-glycosides, grincamycins L-N (1-3), together with the known rabelomycin (4), moromycin B (5), fridamycin D (6), saquayamycin B1 (7), actinomycin X2 (8), and actinomycin D (9), were isolated from the culture of the soil-derived Streptomyces sp. XZHG99T collected from Color desert, Dengpa District, Tibet. The structures of 1-3 were established by detailed analyses of comprehensive spectroscopic data. Compounds 1-9 exhibited significant cytotoxicity against a panel of human cancer cell lines A549, H157, MCF7, MDA-MB-231, and HepG2, while 4, 8, and 9 showed decent antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus.

PMID:
30158647
DOI:
10.1038/s41429-018-0096-1
[Indexed for MEDLINE]

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