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Chimia (Aarau). 2018 Aug 22;72(7):514-517. doi: 10.2533/chimia.2018.514.

Mesoporous Silica for Triphase Nucleophilic Substitution Reactions.

Author information

1
Technology Centre of China Tobacco Guangxi Industrial Co., LTD, Guangxi Province 530001, China.
2
Department of chemistry, Fudan University, Shanghai 200433, China;, Email: jiji@fudan.edu.cn.
3
Department of Chemistry and Biochemistry, Texas State University-San Marcos, 601 University Drive, San Marcos, Texas 78666, USA.
4
Department of chemistry, Fudan University, Shanghai 200433, China.

Abstract

Mesoporous silica SBA-15 is shown to be a very efficient alternative to phase transfer catalyst salts for two-phase nucleophilic substitutions. The two-phase reaction can efficiently take place in the absence of PTCs. The high catalytic activity and reaction rates can be attributed to the amphiphilic and negatively charged surface of SBA-15 as well as the rapid ingress of the reactants and egress of the products.

PMID:
30158015
DOI:
10.2533/chimia.2018.514

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