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J Ovarian Res. 2018 Aug 29;11(1):71. doi: 10.1186/s13048-018-0443-7.

The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention.

Guo H1,2, Guo J1,2, Xie W1,3, Yuan L4, Sheng X5,6.

Author information

1
Department of Gynecologic Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
2
School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
3
Shandong University, Jinan, Shandong, China.
4
Department of Gynecologic Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China. ylqsd@aliyun.com.
5
Department of Gynecologic Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China. shengxiugui@163.com.
6
Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center, Guangdong, China. shengxiugui@163.com.

Abstract

Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer prevention by regulating cellular proliferation and metabolism. Studies of the cellular mechanism of vitamin D in ovarian cancer strongly suggest that it exhibits protective and antitumorigenic activities through genomic and nongenomic signal transduction pathways. These results indicate that vitamin D deficiency results in an increase in the risk of developing ovarian cancer and that vitamin supplements may potentially be an efficient way of preventing cancer. Consequently, this review describes the epidemiology, molecular mechanism and evidence linking vitamin D deficiency to ovarian cancer.

KEYWORDS:

1,25(oh)2D3; Angiogenesis; Inflammatory; Metastasis; Ovarian cancer; Prevention; Tumor metabolism

PMID:
30157901
PMCID:
PMC6114234
DOI:
10.1186/s13048-018-0443-7
[Indexed for MEDLINE]
Free PMC Article

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