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J Transl Med. 2018 Aug 29;16(1):235. doi: 10.1186/s12967-018-1616-2.

The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia.

Author information

1
Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, 10 Youanmen Xitoutiao, Beijing, 100069, China.
2
Center for Physical Examination, Xuanwu Hospital, Capital Medical University, Beijing, 100050, China.
3
School of Medical Sciences, Edith Cowan University, Perth, WA, 6027, Australia.
4
Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, 10 Youanmen Xitoutiao, Beijing, 100069, China. wangy@ccmu.edu.cn.
5
School of Medical Sciences, Edith Cowan University, Perth, WA, 6027, Australia. wangy@ccmu.edu.cn.
6
Genos Glycobiology Research Laboratory, 10000, Zagreb, Croatia.
7
Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000, Zagreb, Croatia.

Abstract

BACKGROUND:

Alternative N-glycosylation has significant structural and functional consequences on immunoglobulin G (IgG) and can affect immune responses, acting as a switch between pro- and anti-inflammatory IgG functionality. Studies have demonstrated that IgG N-glycosylation is associated with ageing, body mass index, type 2 diabetes and hypertension.

METHODS:

Herein, we have demonstrated patterns of IgG glycosylation that are associated with blood lipids in a cross-sectional study including 598 Han Chinese aged 20-68 years. The IgG glycome composition was analysed by ultra-performance liquid chromatography.

RESULTS:

Blood lipids were positively correlated with glycan peak GP6, whereas they were negatively correlated with GP18 (P < 0.05/57). The canonical correlation analysis indicated that initial N-glycan structures, including GP4, GP6, GP9-12, GP14, GP17, GP18 and GP23, were significantly correlated with blood lipids, including total cholesterol, total triglycerides (TG) and low-density lipoprotein (r = 0.390, P < 0.001). IgG glycans patterns were able to distinguish patients with dyslipidaemia from the controls, with an area under the curve of 0.692 (95% confidence interval 0.644-0.740).

CONCLUSIONS:

Our findings indicated that a possible association between blood lipids and the observed loss of galactose and sialic acid, as well as the addition of bisecting GlcNAcs, which might be related to the chronic inflammation accompanying with the development and procession of dyslipidaemia.

KEYWORDS:

Blood lipids; Dyslipidaemia; Immunoglobulin G; N-Glycosylation

PMID:
30157878
PMCID:
PMC6114873
DOI:
10.1186/s12967-018-1616-2
[Indexed for MEDLINE]
Free PMC Article

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