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J Biomed Sci. 2018 Aug 29;25(1):65. doi: 10.1186/s12929-018-0469-6.

H. pylori infection and extra-gastroduodenal diseases.

Author information

1
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital and National Yang-Ming University, 386 Ta Chung 1st Road, Kaohsiung, 813, Taiwan, Republic of China.
2
Cheng Shiu University, Kaohsiung, Taiwan, Republic of China.
3
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital and National Yang-Ming University, 386 Ta Chung 1st Road, Kaohsiung, 813, Taiwan, Republic of China. williamhsup@yahoo.com.tw.

Abstract

Helicobacter pylori infection is the principal cause of peptic ulcer disease, gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. Recent studies have shown that it may interfere with many biological processes and determine or influence the occurrence of many diseases outside the stomach. Currently, the role of H. pylori in idiopathic thrombocytopenic purpura and iron deficiency anemia is well documented. Emerging evidence suggests that it may also contribute to vitamin B12 deficiency, insulin resistance, metabolic syndrome, diabetes mellitus and non-alcoholic liver disease. Additionally, it may increase the risk of acute coronary syndrome, cerebrovascular disease, neurodegenerative disease and other miscellaneous disorders. Different pathogenic mechanisms have been hypothesized, including the occurrence of molecular mimicry and the induction of a low-grade inflammation. This review summarizes the results of the most relevant studies on the extra-gastroduodenal manifestations of H. pylori infection.

KEYWORDS:

Helicobacter pylori; Idiopathic thrombocytopenic purpura and vitamin B12 deficiency; Iron deficiency anemia

PMID:
30157866
PMCID:
PMC6114542
DOI:
10.1186/s12929-018-0469-6
[Indexed for MEDLINE]
Free PMC Article

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