Sepsis-induced acute kidney injury: kidney protection effects by antioxidants

Rev Bras Enferm. 2018 Jul-Aug;71(4):1921-1927. doi: 10.1590/0034-7167-2017-0469.
[Article in English, Portuguese]

Abstract

Objective: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats.

Methods: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdominal sepsis), sepsis (experimental model of sepsis with cecal ligation and puncture), N-acetylcysteine + sepsis and diosmin-hesperidin + sepsis. The evaluation contemplated physiological parameters (temperature, glycemia, and average blood pressure), kidney function (creatinine clearance), oxidative stress (urinary peroxides) and kidney histology.

Results: The animals submitted to cecal ligation and puncture (sepsis) presented lower body temperature, lower average blood pressure, reduced creatinine clearance and increased urinary hydrogen peroxide levels. Treatment with diosmin-hesperidin improved kidney function and led to a reduction in the excretion of oxidative metabolites.

Conclusion: The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury.

MeSH terms

  • Acetylcysteine / pharmacology
  • Acetylcysteine / therapeutic use
  • Acute Kidney Injury / drug therapy*
  • Acute Kidney Injury / prevention & control
  • Animals
  • Antioxidants / pharmacology*
  • Antioxidants / therapeutic use
  • Brazil
  • Cecum / drug effects
  • Cecum / injuries
  • Diosmin / pharmacology
  • Diosmin / therapeutic use
  • Disease Models, Animal
  • Hesperidin / pharmacology
  • Hesperidin / therapeutic use
  • Oxidative Stress / drug effects*
  • Rats
  • Sepsis / complications*
  • Sepsis / drug therapy

Substances

  • Antioxidants
  • Diosmin
  • Hesperidin
  • Acetylcysteine