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Chem Commun (Camb). 2018 Sep 11;54(73):10336-10339. doi: 10.1039/c8cc06298f.

Hairpin-fuelled catalytic nanobeacons for amplified microRNA imaging in live cells.

Author information

1
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, China. jinhuang@hnu.edu.cn kmwang@hnu.edu.cn.

Abstract

Direct imaging of low-abundance RNAs in live cells remains challenging because of the relatively low sensitivity of conventional molecular imaging probes. Here, we introduce hairpin-fuelled catalytic nanobeacons for microRNA (miRNA) imaging in live cells with signal amplification capacity. Compared with the conventional nanobeacons in solution, the catalytic nanobeacons could generate two orders of magnitude higher sensitivity.

PMID:
30151514
DOI:
10.1039/c8cc06298f
[Indexed for MEDLINE]

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