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In Vivo. 2018 Sep-Oct;32(5):977-981. doi: 10.21873/invivo.11338.

Vitamin D in Cardiovascular Disease.

Author information

1
Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
2
Biochemistry & Microbiology Laboratory, Hipokrateion Hospital, Athens, Greece.
3
Health Center, National Health System, Areopolis, Greece.
4
Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece mkoutsil@med.uoa.gr.

Abstract

Cardiovascular disease is the prevalent cause of morbidity and mortality in the world, affecting many millions of individuals every year. Atherosclerosis, a chronic inflammatory condition that involves different cell types, several cytokines and adhesion molecules, is the underlying cause of cardiovascular disease. Vitamin D is known to control skeletal patho/physiology, regulating calcium and phosphorus and bone remodeling along with other calcium-regulating hormones. However, several active metabolites of vitamin D can exert both direct action, mainly via vitamin D3 receptor trans-activation and indirect actions on several other tissues by an endocrine, autocrine and paracrine manners. With regard to cardiovascular disease, vitamin D deficiency has been associated with activation of the pro-inflammatory mechanism, promoting atherogenesis. There are several large-scale clinical studies, as well as meta-analyses that support this finding. However, it is still unclear whether the plasma 25-hydroxyvitamin D level can be used as a biomarker for future cardiovascular disease. Herein we review the studies reporting a causative role for vitamin D in cardiovascular disease.

KEYWORDS:

Atherosclerosis; cardiovascular disease; matrix metalloproteinases; review; vitamin D; vitamin D receptor

PMID:
30150419
PMCID:
PMC6199603
DOI:
10.21873/invivo.11338
[Indexed for MEDLINE]
Free PMC Article

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