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Med Mycol Case Rep. 2017 Dec 21;20:4-6. doi: 10.1016/j.mmcr.2017.12.002. eCollection 2018 Jun.

Necrotizing fasciitis caused by Apophysomyces variabilis in an immunocompetent patient.

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Centro de Investigaciones Microbiológicas del Cesar (CIMCE), Hospital Rosario Pumarejo de Lopez, Clínica Laura Daniela, Clínica médicos LTDA, Valledupar, Colombia.
Microbiology Program Universidad Popular del Cesar, Valledupar, Colombia.
Universidad Nacional de Colombia, Medicine Faculty and Clínica Universitaria Colombia, Colsanitas, Bogota, Colombia.
Molecular Biotechnology Research Group, Corporación CorpoGen, Bogotá, Colombia.
Clínica Erasmo, Valledupar, Colombia.


Mucormycosis caused by Apophysomyces variabilis is rarely reported in humans. A case of A. variabilis infection in an immunocompetent men after friction burns in a car accident is described. The infection presented as a rapidly progressive necrotizing infection of the skin and soft tissue, which required extensive surgical debridement and total colonic defunctioning colostomy associated with prolonged antifungal therapy. A. variabilis infection should be considered as a differential diagnosis of rapidly progressive necrotizing skin and soft tissue infections in immunocompetent individuals.


Amphotericin B; Apophysomyces variabilis; Mucormycosis; Zygomycetes

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