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Indian J Cancer. 2018 Jan-Mar;55(1):98-104. doi: 10.4103/ijc.IJC_503_17.

Prognostic factors in parotid cancers: Clinicopathological and treatment factors influencing outcomes.

Author information

Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
Department of Radiotherapy, Tata Memorial Hospital, Mumbai, Maharashtra, India.



Parotid cancers are uncommon and have a relatively long natural history. Determination of prognostic factors affecting the outcome is difficult.

Materials and Methods:

The primary objective was to determine the demographic, clinical, histopathology and treatment-related factors affecting overall survival (OS) in parotid cancers. The secondary objective was to study the impact of these factors on disease-free survival (DFS) and patterns of failure. Data of consecutive patients who underwent parotidectomy for primary parotid malignancy between July 2006 and April 2015 with at least 6 months of posttreatment follow-up were retrospectively retrieved. Patients whose follow-up status was known at the time of analysis were included. One hundred and sixty-five patients met the inclusion criteria.


The median follow-up was 38 months. The mean OS and DFS were 141.03 and 124.38 months, respectively. Age > 45 years affected both OS and DFS (P = 0.00 and 0.002 respectively) adversely. Advanced T stage affected adversely OS in univariate (P = 0.00) but not in multivariate analysis (P = 0.91) and DFS in both univariate (P = 0.00) and multivariate analysis (P = 0.005). Nodal positivity adversely affected survival adversely in univariate (P = 0.00 for OS and DFS) and multivariate analysis (P = 0.022 for OS and P = 0.001 for DFS). Resection margin of < 5mm affected OS as compared to a margin of ≥5mm (P = 0.03).


Nodal positivity is the single most important factor affecting survival in parotid cancers. A histopathological resection margin of at least 5 mm is desirable. Advanced age along with high grade, advanced T and N stages need to be considered for adjuvant treatment.


Lymphatic metastasis; parotid cancers; parotid neoplasms; prognostic factors; retrospective studies; risk assessment; survival analysis

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