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Graefes Arch Clin Exp Ophthalmol. 2018 Nov;256(11):2211-2217. doi: 10.1007/s00417-018-4112-8. Epub 2018 Aug 25.

Short-term effects of low-concentration atropine eye drops on pupil size and accommodation in young adult subjects.

Author information

1
Internationale Innovative Ophthalmochirurgie GbR, c/o Breyer Kaymak and Klabe Augenchirurgie, Martin-Luther-Platz 22, 40212, Düsseldorf, Germany. h.kaymak@augenchirurgie.clinic.
2
Internationale Innovative Ophthalmochirurgie GbR, c/o Breyer Kaymak and Klabe Augenchirurgie, Martin-Luther-Platz 22, 40212, Düsseldorf, Germany.
3
Department of Ophthalmology, Saarland University Medical Center, Kirrbergerstr. 100, Gebäude 22, 66424, Homburg, Germany.
4
Institute of Experimental Ophthalmology, Saarland University Medical Center, Kirrbergerstr. 100, Gebäude 22, 66424, Homburg, Germany.
5
Eberhard Karls Universität Tübingen, Section of Neurobiology of the Eye, Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tübingen, Elfriede-Aulhorn-Strasse, 772076, Tübingen, Germany.

Abstract

PURPOSE:

A single eye drop containing 0.01% atropine every evening has previously been found to inhibit myopia progression in young adults. We have tested the short-term effects of very low-dose atropine eye drops on pupil sizes and accommodation in young adult subjects.

METHODS:

Fourteen eyes of young adult subjects participated in the clinical observation. A single eye drop was applied with concentrations of either 0.01%, 0.005%, or 0.001% in the evening. Baseline parameters were measured before atropine application. Changes of pupil sizes, under photopic and mesopic conditions, as well as accommodation amplitudes were observed over the next day and analyzed by paired the Wilcoxon signed-rank test.

RESULTS:

The pupil was significantly dilated 12 h after instillation of 0.01% atropine eye drops, both under photopic (3.3 ± 0.5 mm vs. 4.9 ± 0.9 mm) and mesopic (4.8 ± 0.7 mm vs. 6.1 ± 0.7 mm) conditions. Pupil sizes recovered over the day but were still significantly larger in the evening, compared to the baseline parameters measured on the day before (3.9 ± 0.5 mm vs. 5.3 ± 0.6 mm). The subjective near point of accommodation was reduced from 8.0 ± 2.4 to 6.6 ± 2.8 dpt in the morning and to 7.0 ± 2.9 dpt in the evening. At 0.005%, the pattern of results remained still similar, although the magnitude of the effects was generally smaller. At 0.001%, pupil sizes were still weakly significantly larger in the morning.

CONCLUSIONS:

At a dose of 0.01%, clinically significant short-term effects were detected on pupil size and accommodation for at least 24 h. At the lowest dose of 0.001%, only tiny effects on pupil size were detectable.

KEYWORDS:

Accommodation; Atropine; Eye drops; Myopia; Pupil size

PMID:
30145612
PMCID:
PMC6208716
DOI:
10.1007/s00417-018-4112-8
[Indexed for MEDLINE]
Free PMC Article

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