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Colloids Surf B Biointerfaces. 2018 Dec 1;172:136-142. doi: 10.1016/j.colsurfb.2018.08.031. Epub 2018 Aug 18.

Synthesis of temperature/pH dual-sensitive supramolecular micelles from β-cyclodextrin-poly(N-isopropylacrylamide) star polymer for drug delivery.

Author information

1
School of Chemistry and Materials Science, Ludong University, Yantai, 264025, China.
2
School of Chemistry and Materials Science, Ludong University, Yantai, 264025, China. Electronic address: guiyingli@126.com.

Abstract

In this paper, temperature and pH dual-sensitive supramolecular micelles were constructed from star polymer β-cyclodextrin-poly(N-isopropylacrylamide) (β-CD-PNIPAM) and benzimidazole terminated poly(ε-caprolactone) (BM-PCL). The supramolecular micelles were formed based on the reversible host-guest recognition between β-CD and BM. The size of supramolecular micelles was about 50-100 nm and the LCST was about 30.5 ℃. The drug loading efficiency of supramolecular micelles for DOX was high due to the hydrophobic micelles core of PCL and hydrophobic cavity of β-CD. The release of drugs from supramolecular micelles was suppressed at neutral solution and room temperature but accelerated at acidic solution and 37 ℃. The drug loaded supramolecular micelles exhibited higher anti-cancer activity than free drugs. These temperature and pH dual-sensitive supramolecular micelles might possess potential applications for anticancer drug delivery.

KEYWORDS:

Controlled release; Host-guest recognition; Poly(N-isopropylacrylamide); Star polymers; β-Cyclodextrin

PMID:
30145459
DOI:
10.1016/j.colsurfb.2018.08.031
[Indexed for MEDLINE]

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