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Curr Opin Virol. 2018 Dec;33:106-112. doi: 10.1016/j.coviro.2018.08.001. Epub 2018 Aug 23.

Genome packaging in multi-segmented dsRNA viruses: distinct mechanisms with similar outcomes.

Author information

1
Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
2
Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.
3
Department of Biology, Indiana University, Bloomington, IN 47405, USA. Electronic address: jtpatton@iu.edu.

Abstract

Segmented double-stranded (ds)RNA viruses share remarkable similarities in their replication strategy and capsid structure. During virus replication, positive-sense single-stranded (+)RNAs are packaged into procapsids, where they serve as templates for dsRNA synthesis, forming progeny particles containing a complete equimolar set of genome segments. How the +RNAs are recognized and stoichiometrically packaged remains uncertain. Whereas bacteriophages of the Cystoviridae family rely on specific RNA-protein interactions to select appropriate +RNAs for packaging, viruses of the Reoviridae instead rely on specific inter-molecular interactions between +RNAs that guide multi-segmented genome assembly. While these families use distinct mechanisms to direct +RNA packaging, both yield progeny particles with a complete set of genomic dsRNAs.

PMID:
30145433
PMCID:
PMC6289821
DOI:
10.1016/j.coviro.2018.08.001
[Indexed for MEDLINE]
Free PMC Article

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