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Environ Res. 2018 Nov;167:558-566. doi: 10.1016/j.envres.2018.08.023. Epub 2018 Aug 18.

Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and neurodevelopmental outcomes: A systematic review and meta-analysis.

Author information

1
Department of Preventive Medicine, College of Medicine, Seoul National University, 103 Daehangno, Jongno-gu, Seoul 110-799, Republic of Korea.
2
Environmental Health Centre, College of Medicine, Seoul National University, Seoul, Republic of Korea; Institute of Environmental Medicine, Medical Research Centre, Seoul National University, Seoul, Republic of Korea.
3
Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea.
4
Department of Preventive Medicine, College of Medicine, Seoul National University, 103 Daehangno, Jongno-gu, Seoul 110-799, Republic of Korea; Environmental Health Centre, College of Medicine, Seoul National University, Seoul, Republic of Korea; Institute of Environmental Medicine, Medical Research Centre, Seoul National University, Seoul, Republic of Korea. Electronic address: ychong1@snu.ac.kr.

Abstract

BACKGROUND:

Di-(2-ethylhexyl) phthalate (DEHP), the most widely used phthalate, has recently been associated with neurodevelopmental disturbances in children. However, the risk is yet to be quantified. Therefore, a systematic review and meta-analysis focusing on the association between exposure to DEHP and neurodevelopmental outcomes is necessary, with particular attention to study design (longitudinal vs. cross-sectional).

METHODS:

We performed a comprehensive literature search for associations between exposure to DEHP and neurodevelopmental outcomes. Among 106 published studies found in public databases, eight longitudinal studies and two cross-sectional studies were included in the meta-analysis.

RESULTS:

We observed a statistically significant association between the concentrations of DEHP metabolites and the neurodevelopment outcomes of children among cross-sectional results, and found significant association between DEHP exposure measured in prenatal period and the psychomotor development outcomes measured later in childhood.

CONCLUSIONS:

To our knowledge, this is the first meta-analysis of studies investigating the association between DEHP exposure and neurodevelopment in children. A need exists for more researches and a precautionary policy for potential health hazard of DEHP, the most commonly used phthalate, to promote healthier neurodevelopment in children.

KEYWORDS:

Intelligence; Meta-analysis; Neurodevelopment; Phthalate; di-(2-ethylhexyl) phthalate

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