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Am J Med. 2019 Feb;132(2):161-167. doi: 10.1016/j.amjmed.2018.08.011. Epub 2018 Aug 24.

Atypical Hemolytic Uremic Syndrome: Beyond Hemolysis and Uremia.

Author information

1
Division of Hematology/Oncology, State University of New York Downstate Medical Center, Brooklyn, NY. Electronic address: hmtsai@gmail.com.

Abstract

Atypical hemolytic uremic syndrome commonly presents with the triad of microangiopathic hemolytic anemia, thrombocytopenia, and renal function impairment without an antecedent hemorrhagic diarrhea. Less known are extrarenal complications due to abnormal vascular permeability, although these are a major cause of morbidity and mortality for the patients. Furthermore, it is increasingly recognized that the disease may present with hypertension or renal function impairment with no or mild thrombocytopenia and microangiopathic hemolytic anemia. Awareness of the full spectrum of atypical hemolytic uremic syndrome may facilitate its diagnosis and treatment before serious complications or death occurs.

KEYWORDS:

Atypical hemolytic uremic syndrome; Hypertension; Microangiopathic hemolytic anemia; Renal failure; Syndrome of hemolysis; Thrombotic microangiopathy; elevated liver enzyme; low platelet count

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