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Infect Genet Evol. 2018 Nov;65:380-384. doi: 10.1016/j.meegid.2018.08.020. Epub 2018 Aug 23.

The possible origin of human adenovirus type 3: Evidence of natural genetic recombination between human and simian adenovirus.

Author information

1
College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea.
2
College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea; BioCore Co., Ltd, 33 Digitalro 9-ghil, Geumcheon-gu, Seoul, Republic of Korea.
3
College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea. Electronic address: odssey@konkuk.ac.kr.

Abstract

We determined a complete genome sequence of the Korean field strain, KUMC-62, of human adenovirus type 3 (HAdV-3) and performed comparative genome analyses. Interestingly HAdV-3 has a distinct genomic sequence for the fiber CDS region on average 62.46% of nucleotide sequence identity to other types of HAdV-B1, while remaining genomic region of HAdV-3 is very similar (on average 95.71% of nucleotide sequence identity) to other types of HAdV-B1. The blast results showed that the fiber CDS region of HAdV-3 exhibited the highest nucleotide sequence identity with that of simian adenovirus type 32 (SAdV-32), except other strains of HAdV-3. In the Simplot analysis, a potential recombination event was detected between HAdV-7 and SAdV-32, which might have created HAdV-3 in the past. These findings suggest that HAdV-3 highly likely was created by a natural inter-species recombination event between human and non-human primate AdVs.

KEYWORDS:

Comparative genome analysis; High-throughput sequencing; Human adenovirus type 3; Recombination; Simian adenovirus

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