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Biotechnol Appl Biochem. 2018 Nov;65(6):761-767. doi: 10.1002/bab.1689. Epub 2018 Sep 19.

Epigenetic changes due to physical activity.

Author information

1
Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
2
Faculty of Physical Education and Sports Sciences, Gilan University, Gilan, Iran.
3
Nutritional Health Research Center, Health and Nutrition Department, Lorestan University of Medical Sciences, Khorramabad, Iran.

Abstract

One of the epigenetic-modifying factors is regular and continuous physical activity. This article attempts to investigate the effects of physical activity and exercise on changes in histone proteins and gene expression, as well as the effect of these exercises on the prevention of certain cancers and the ejection of age-related illnesses and cellular oxidation interactions. All of this is due to epigenetic changes and gene expression. Most studies have reported the positive effects of regular exercises on the expression of histone proteins. DNA methylation and the prevention of certain diseases such as cancer and respiratory diseases, caused by antioxidative interactions that occur more often in the elderly, have been studied.

KEYWORDS:

DNA methylation; MiRNA; epigenetics; histone proteins; sports exercises

PMID:
30144174
DOI:
10.1002/bab.1689
[Indexed for MEDLINE]

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