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Anal Chim Acta. 2018 Nov 22;1032:1-17. doi: 10.1016/j.aca.2018.05.011. Epub 2018 May 4.

Early diagnosis of disease using microbead array technology: A review.

Author information

1
Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
2
Biomedical Engineering Department, Maziar University, Noor, Royan, Iran.
3
Department of Chemistry, Shahid Beheshti University, Tehran, Iran.
4
Marquette University School of Dentistry, Milwaukee, WI 53233, USA. Electronic address: mohammadreza.tahriri@marquette.edu.
5
Marquette University School of Dentistry, Milwaukee, WI 53233, USA.
6
Electrical and Computer Engineering Department, North Carolina State University, Raleigh, NC 27606, USA.
7
Marquette University School of Dentistry, Milwaukee, WI 53233, USA; Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, CA 94304, USA.
8
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA. Electronic address: hamblin@helix.mgh.harvard.edu.

Abstract

Early diagnosis of diseases (before they become advanced and incurable) is essential to reduce morbidity and mortality rates. With the advent of novel technologies in clinical laboratory diagnosis, microbead-based arrays have come to be recognized as an efficient approach, that demonstrates useful advantages over traditional assay methods for multiple disease-related biomarkers. Multiplexed microbead assays provide a robust, rapid, specific, and cost-effective approach for high-throughput and simultaneous screening of many different targets. Biomolecular binding interactions occur after applying a biological sample (such as blood plasma, saliva, cerebrospinal fluid etc.) containing the target analyte(s) to a set of microbeads with different ligand-specificities that have been coded in planar or suspension arrays. The ligand-receptor binding activity is tracked by optical signals generated by means of flow cytometry analysis in the case of suspension arrays, or by image processing devices in the case of planar arrays. In this review paper, we discuss diagnosis of cancer, neurological and infectious diseases by using optically-encoded microbead-based arrays (both multiplexed and single-analyte assays) as a reliable tool for detection and quantification of various analytes.

KEYWORDS:

Biomarker; Cancer; Early diagnosis; Infectious disease; Microbead array applications; Multiplexing; Neurological disease

PMID:
30143206
PMCID:
PMC6152944
[Available on 2019-11-22]
DOI:
10.1016/j.aca.2018.05.011
[Indexed for MEDLINE]

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