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Genome Biol. 2018 Aug 24;19(1):125. doi: 10.1186/s13059-018-1486-1.

HiGlass: web-based visual exploration and analysis of genome interaction maps.

Author information

1
Department of Biomedical Informatics, Harvard Medical School, Countway Library, 10 Shattuck St, Boston, MA, 02115, USA.
2
Computational and Systems Biology Program, MIT, Cambridge, USA.
3
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
4
Bioinformatics and Integrative Genomics Program, Harvard Medical School, Boston, MA, USA.
5
Department of Physics, MIT, Cambridge, USA.
6
Institute for Medical Engineering and Science, MIT, Cambridge, USA.
7
Department of Biomedical Informatics, Harvard Medical School, Countway Library, 10 Shattuck St, Boston, MA, 02115, USA. nils@hms.harvard.edu.

Abstract

We present HiGlass, an open source visualization tool built on web technologies that provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps alongside 1D genomic tracks, allowing users to combine various data types, synchronize multiple visualization modalities, and share fully customizable views with others. We demonstrate its utility in exploring different experimental conditions, comparing the results of analyses, and creating interactive snapshots to share with collaborators and the broader public. HiGlass is accessible online at http://higlass.io and is also available as a containerized application that can be run on any platform.

KEYWORDS:

Chromosome conformation; Data visualization; Genomics; Hi-C

PMID:
30143029
PMCID:
PMC6109259
DOI:
10.1186/s13059-018-1486-1
[Indexed for MEDLINE]
Free PMC Article

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