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J Clin Med. 2018 Aug 23;7(9). pii: E236. doi: 10.3390/jcm7090236.

Association of Arrhythmia in Patients with Cervical Spondylosis: A Nationwide Population-Based Cohort Study.

Lin SY1,2, Hsu WH3,4, Lin CC5,6, Lin CL7,8, Tsai CH9,10, Lin CH11,12, Chen DC13, Lin TC14, Hsu CY15, Kao CH16,17,18.

Author information

1
Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan. oasisbestonly@yahoo.com.tw.
2
Division of Nephrology and Kidney Institute, China Medical University Hospital, Taichung 404, Taiwan. oasisbestonly@yahoo.com.tw.
3
Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan. Hsuwh@mail.cmuh.org.tw.
4
Division of Pulmonary and Critical Care Medicine, China Medical University Hospital and China Medical University, Taichung 404, Taiwan. Hsuwh@mail.cmuh.org.tw.
5
Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan. cclin@mail.cmuh.org.tw.
6
Department of Family Medicine, China Medical University Hospital, Taichung 404, Taiwan. cclin@mail.cmuh.org.tw.
7
Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan. orangechengli@gmail.com.
8
College of Medicine, China Medical University, Taichung 404, Taiwan. orangechengli@gmail.com.
9
Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan. D7940@mail.cmuh.org.tw.
10
Department of Orthopedics, China Medical University Hospital, Taichung 404, Taiwan. D7940@mail.cmuh.org.tw.
11
Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan. d5496@mail.cmuh.org.tw.
12
Department of Family Medicine, China Medical University Hospital, Taichung 404, Taiwan. d5496@mail.cmuh.org.tw.
13
Department of Orthopedics, China Medical University Hospital, Taichung 404, Taiwan. D16240@mail.cmuh.org.tw.
14
Department of Orthopedics, St. Martin De Porres Hospital, Chiayi 600, Taiwan. zunlin999@gmail.com.
15
Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan. hsuc@mail.cmuh.org.tw.
16
Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan. d10040@mail.cmuh.org.tw.
17
Department of Nuclear Medicine, China Medical University Hospital, Taichung 404, Taiwan. d10040@mail.cmuh.org.tw.
18
Department of Bioinformatics and Medical Engineering, Asia University, Taichung 413, Taiwan. d10040@mail.cmuh.org.tw.

Abstract

BACKGROUND:

Sympathetic activity, including cervical ganglia, is involved in the development of cardiac arrhythmias.

OBJECTIVE:

The present study investigated the association between cervical spondylosis and arrhythmia, which has never been reported before.

METHODS:

Patients newly diagnosed with cervical spondylosis (CS) with an index date between 2000 and 2011 were identified from the National Health Insurance Research Database. We performed a 1:1 case-control matched analysis. Cases were matched to controls according to their estimated propensity scores, based on demographics and existing risk factors. Cox proportional hazard models were applied to assess the association between CS and arrhythmia.

RESULTS:

The CS cohort comprised 22,236 patients (males, 42.6%; mean age, 54.4 years) and non-CS cohort comprised 22,236 matched controls. There were 1441 events of arrhythmia in CS cohort and 537 events of arrhythmia in non-CS cohort, which 252 and 127 events of atrial fibrillation in CS and non-CS cohort, 33 and 12 events of ventricular tachycardia in CS cohort and non-CS cohort, 78 and 35 events of supraventricular tachycardia in CS cohort and non-CS cohort. The CS cohort had an arrhythmia incidence of 11.1 per 1000 person-years and a higher risk [adjusted hazard ratio (aHR) = 3.10, 95% confidence interval (CI) = 2.80⁻3.42] of arrhythmia, 2.54-fold aHR of ventricular tachycardia (95% CI = 1.70⁻3.79), and 2.22-fold aHR of atrial fibrillation (95% CI = 1.79⁻2.76) compared with non-CS cohort.

CONCLUSIONS:

Cervical spondylosis is associated with a higher risk of arrhythmia.

KEYWORDS:

arrhythmia; cervical spondylosis; population cohort study

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