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Neuroimage. 2018 Dec;183:456-468. doi: 10.1016/j.neuroimage.2018.08.050. Epub 2018 Aug 22.

The Lifespan Human Connectome Project in Development: A large-scale study of brain connectivity development in 5-21 year olds.

Author information

1
Department of Psychology, Harvard University, Cambridge, MA, USA; Center for Brain Science, Harvard University, Cambridge, MA, USA. Electronic address: somerville@fas.harvard.edu.
2
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.
3
Department of Psychology, Harvard University, Cambridge, MA, USA; Center for Brain Science, Harvard University, Cambridge, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
4
Department of Psychiatry, Washington University Medical School, St. Louis, MO, USA.
5
Department of Neuroscience, Washington University Medical School, St. Louis, MO, USA.
6
Department of Psychology, Harvard University, Cambridge, MA, USA; Center for Brain Science, Harvard University, Cambridge, MA, USA.
7
Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, UK; Department of Statistics, University of Warwick, Coventry, UK; Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
8
Department of Psychiatry, Washington University Medical School, St. Louis, MO, USA; Department of Neuroscience, Washington University Medical School, St. Louis, MO, USA; Department of Neurology, Washington University Medical School, St. Louis, MO, USA; Department of Pediatrics, Washington University Medical School, St. Louis, MO, USA; Department of Radiology, Washington University Medical School, St. Louis, MO, USA.
9
Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
10
Institute of Child Development, University of Minnesota, Minneapolis, MN, USA.
11
Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
12
Department of Psychiatry, Washington University Medical School, St. Louis, MO, USA; Department of Radiology, Washington University Medical School, St. Louis, MO, USA; Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.

Abstract

Recent technological and analytical progress in brain imaging has enabled the examination of brain organization and connectivity at unprecedented levels of detail. The Human Connectome Project in Development (HCP-D) is exploiting these tools to chart developmental changes in brain connectivity. When complete, the HCP-D will comprise approximately ∼1750 open access datasets from 1300 + healthy human participants, ages 5-21 years, acquired at four sites across the USA. The participants are from diverse geographical, ethnic, and socioeconomic backgrounds. While most participants are tested once, others take part in a three-wave longitudinal component focused on the pubertal period (ages 9-17 years). Brain imaging sessions are acquired on a 3 T Siemens Prisma platform and include structural, functional (resting state and task-based), diffusion, and perfusion imaging, physiological monitoring, and a battery of cognitive tasks and self-reports. For minors, parents additionally complete a battery of instruments to characterize cognitive and emotional development, and environmental variables relevant to development. Participants provide biological samples of blood, saliva, and hair, enabling assays of pubertal hormones, health markers, and banked DNA samples. This paper outlines the overarching aims of the project, the approach taken to acquire maximally informative data while minimizing participant burden, preliminary analyses, and discussion of the intended uses and limitations of the dataset.

KEYWORDS:

Adolescent; Brain; Child; Connectivity; Connectome; Development; MRI; Network; Neurodevelopment

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