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Biosystems. 2018 Aug 22. pii: S0303-2647(18)30171-0. doi: 10.1016/j.biosystems.2018.08.007. [Epub ahead of print]

Integration of intracellular signaling: Biological analogues of wires, processors and memories organized by a centrosome 3D reference system.

Author information

1
Independent researcher, Saint-Petersburg, Russia.
2
Monash University, School of Biomedical Sciences, Department of Biochemistry and Molecular Biology, VIC, 3800, Australia.
3
Medical Clininc I, Cardiology/Angiology, University Hospital, Justus-Liebig-University, Giessen, Germany.
4
Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
5
Instituto de Medicina Molecular, Instituto de Bioquimica, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
6
Sechenov Institute of Evolutionary Physiology and Biochemistry, Saint-Petersburg, Russia.
7
Department of Bioengineering and Mathematical Modeling, AudioLogic, Milan, Italy.
8
Department of Oncology, University of Alberta, Edmonton, Alberta, Canada; Department of Physics, University of Alberta, Edmonton, Alberta, Canada; Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, IT-10128, Torino, Italy. Electronic address: jackt@ualberta.ca.

Abstract

BACKGROUND:

Myriads of signaling pathways in a single cell function to achieve the highest spatio-temporal integration. Data are accumulating on the role of electromechanical soliton-like waves in signal transduction processes. Theoretical studies strongly suggest feasibility of both classical and quantum computing involving microtubules.

AIM:

A theoretical study of the role of the complex composed of the plasma membrane and the microtubule-based cytoskeleton as a system that transmits, stores and processes information.

METHODS:

Theoretical analysis presented here refers to (i) the Penrose-Hameroff theory of consciousness (Orchestrated Objective Reduction; Orch OR), (ii) the description of the centrosome as a reference system for construction of the 3D map of the cell proposed by Regolini, (iii) the Heimburg-Jackson model of the nerve pulse propagation along axons' lipid bilayer as soliton-like electro-mechanical waves.

RESULTS AND CONCLUSION:

The ideas presented in this paper provide a qualitative model for the decision-making processes in a living cell undergoing a differentiation process.

OUTLOOK:

This paper paves the way for the real-time live-cell observation of information processing by microtubule-based cytoskeleton and cell fate decision making.

KEYWORDS:

Centrosome; Memory; Microtubule; Signal transduction; Signaling; Tubulin

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