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Gut Microbes. 2019;10(2):210-215. doi: 10.1080/19490976.2018.1494102. Epub 2018 Aug 24.

Identification of gut microbiome signatures associated with longevity provides a promising modulation target for healthy aging.

Kong F1,2,3, Deng F1,3, Li Y3, Zhao J1.

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a Department of Animal Science, Division of Agriculture , University of Arkansas , Fayetteville , AR , USA.
b College of Life Science , Sichuan Agricultural University , Ya'an , Sichuan , China.
c Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province , Sichuan Agricultural University , Chengdu , Sichuan , China.


The world population is aging, which poses a significant burden to the economy and health care system. As people age, so do their gut microbiomes. Age-related changes in gut microbiome have been reported, including decreased microbial diversity and increased Proteobacteria. Recently, we characterized the gut microbiome of a group of long-living (≥ 90 years old) Chinese people. Interestingly, the diversity of their gut microbiome was greater than that of a young adult control group. We also identified several potentially beneficial bacteria enriched in the long-living Chinese group. These results were validated using data from an independent Italian cohort that included a group of long-living individuals. Other recent studies have found similar results. Here, we provide a summary of these discoveries and discuss their implications in healthy aging.


beneficial bacteria; diversity; gut microbiota; healthy aging

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